Mechanisms of Action for the Coffee Enema
Coffee contains ingredients that stimulate the functioning of the liver when introduced into the body through the colon. These effects are not produced by drinking coffee. Drinking coffee impairs liver activity.
Coffee contains caffeine and salts of palmitic acids (kahweol and cafestol palmitate), which are absorbed by the hepatic portal system located in the last section of the colon. The portal veins carry the caffeine and palmitic acids directly to the liver without digestion.
In the liver, kahweol and cafestol act as potent enhancers of glutathione S-transferase which is an important enzyme in the liver. It is part of a major detoxification system that catalyzes the binding of many toxins from the blood stream to the sulfhydryl group of glutathione so that the toxins can be released into the small intestine and excreted from the body. The caffeine dilates bile ducts and aids the emptying of toxic material from the gallbladder. Finally, the water in the enema stimulates activity of the intestines, which systematically moves the toxic substances released by the liver and gallbladder through the intestines so that they can be released out of the body through the rectum.